Metronidazole has demonstrated evidence of mutagenic activity in several in vitro bacterial assay methods. Moreover, a dose-response rise in the frequency of micronuclei was observed in mice just after intraperitoneal injections and a rise in chromosome aberrations have been reported in individuals with Crohn's disease who were being handled with two hundred-1200 mg/day of metronidazole for one to 24 months.

, and Mycoplasma hominis, hasn't been described. Even so, metronidazole can be an antimicrobial agent Lively in vitro from most strains of the following organisms that were documented being connected with bacterial vaginosis:

Ahead of utilizing metronidazole, inform your doctor or pharmacist When you are allergic to it; or to other nitroimidazole antibiotics (for instance tinidazole); or When you've got almost every other allergic reactions.

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Quickly reevaluate METROGEL therapy if irregular neurologic signs look. Administer metronidazole with warning to patients with central nervous technique health conditions.

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METROGEL® Topical Gel is contraindicated in persons with a historical past of hypersensitivity to metronidazole, parabens, or other elements with the formulation.